IMMUNISATION AGAINST CANCER

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Form and content copyright © Justice Publications - 1999

Click here for a few pseudo semi-technical twiddly-bits .

P53 is the designation given to the genetic component which acts as a brake in cell-subdivision. If it is absent or damaged, cells can replicate without control, and in certain circumstances can become cancer. "All cancer - and pre-cancer - cells are deficient in p53."

Unfortunately, your immune system does not recognise this deficiency in your cells as a fault - It is you. So you yourself cannot eradicate such cells. And if or when their uncontrolled replication becomes cancer, your immune system still insists that - it is you. - Well, it is, isn't it.

But suppose we take a few of my cells, say, and intentionally damage their p53 in a variety of ways, and then replicate this material - or even simply its damaged p53 - in abundance by PCR - or polymerase chain reaction. Then suppose that a few cells of this material are injected into other people, irrespective of whether they yet have cells with damaged or deficient p53. Logically, the following will then have to happen: - Their immune system will wake to the fact that alien - my - cells are present, and will manufacture antibodies against them - including against the p53-deficiency factor. These antibodies then will go to combat any cells deficient in p53, mine and - intentionally - theirs, or will wait for any such cells to appear by natural mischance in the future, and act against them then.

In this way, cells - present now or occurring in the future - which otherwise potentially might result in future cancer, will be suppressed, and their potential cancers will not - will not be able to - occur. This technique may equally be applied to other species, too. Why should they have to suffer cancer unnecessarily?

It is not known how effective this technique will be against established cancers - The fact that 'natural remission' can occur in both leukaemia and other cancers would tend to indicate that the immune system can have a subduing influence even on otherwise progressive cancers, and so lead to the suspicion that maybe this same method just... might... However, as a support to this system, if it were not enough, an enzyme may be attached to the antibodies, which will then take it directly to any p53-deficient cells. Then, when the enzyme has been evacuated from the rest of the body, a pro-drug may be injected, which is activated by the enzyme in the site of the defective cells, eliminating them. - This clever 'adept' technique (antibody directed enzyme-pro-drug therapy) is already in use in destroying existing cancers, but the suggested use of others' cells with intentionally impaired p53 - or even simply of the damaged p53 itself - is offered as a simple method of providing immunity and thus preventing cancers from occurring at all.

If there were cases of the antibodies failing to recognise the host's damaged or deficient p53, it would be a matter of damaging the p53 of each such individual, genetically altering it and the DNA of the host cells and re-inserting these so that the immune system could then not fail to recognise that the rest of the indigenous damaged p53 is also to be suppressed - It would also do this in the case of established cancers, though to what extent as yet is only conjecture - All cancer cells are deficient in p53 however, as an essential component of the syndrome - so this may well be a means of eliminating existing cancers, and it would then prevent the development of cancers in the same person in the future. The simpler comprehensive preventative method is obviously preferable, however, and it is thought that antibodies can - if not doing so automatically - be educated to recognise characteristic damage to p53.

And it is an intriguing thought, isn't it, that perhaps - merely by waking the immune system in this way to suppress its own host's flawed cells - the cancellation of this underlying factor crucial to all cancers might even disrupt the entire cancer syndrome and therefore alone be enough to prevent all the types it can produce - And that maybe, therefore, all that other so-richly lucrative research work will be redundant.

To alter the p53 in the intended vaccine? - Well, you will need the molecular profile of p53, of course, to vary the constituents of the p53 in as many ways as possible, in order to provide the widest array of antibodies against as many variations of naturally-occurring p53-damage as possible. But this is not even very difficult - (gamma, x-, u.v., beta, slow alpha etc, and heat treatment - and the relevant moulds and viruses, remember - the lot - then, if necessary, dried and stored in trehalose at room temperature) - For the right molecular-biology team it will be child's-play - even fun! Some would do it free of charge, I'm sure, for the simple privilege of being able to contribute something so useful - for a change.

It will be necessary to remedy an increasing innate tendency to produce p53-deficient cells in descendants of those who, rather than dying as a result of the cancers that the p53-deficient cells would otherwise produce - thus taking the problem into the grave with them - therefore will instead live, of course, but it is better to cross that bridge when we come to it.

This advice is offered free, and its implementation will be cheap, and should be available to everyone; a mere few cell cultures will be needed with damaged or deficient p53 to be endlessly replicated, a single culture being effective to all except its donor or twin - in both of whom, incidentally, it could promote - not prevent - cancer.

So it will be interesting, won't it, to watch and see which disgusting creatures will try to patent this - not their idea - and so hold the suffering impoverished of humanity to ransom yet again for the sole motive of just more coin, as is done in so many other ways already - Then let us recognise and treat them for the greedy, malignant, pestilential misanthropes they are, too.

- Two birds, one stone.

We might also resolve the patent racket while we're about it - Three.

 

Afterthought: - Obviously, unless a specialist, you are less interested in prevention than in cure; if you haven't cancer now then... perhaps you won't have it...and so prevention is of marginal interest, whereas only if you have cancer will you be desperate for a cure, and this applies to a minority of you as yet. Well let me tell you this: you yourself have p53-deficient cells now which in the future, for unforeseeable reasons totally beyond your knowledge or control, may become cancer. And whether or not it has yet been diagnosed, a percentage of you apparently healthy folk already have cancer, and that is absolutely certain - It has simply not yet been definitively determined who has it and who has not. - Wouldn't it be a much better idea to prevent all that and not even have to consider it?

- So whether you recognise it or not, this is of vital importance to you, too. THE most cost-effective thing governments can do at this moment is to prevent ANY of the population developing cancer, which, at the very least, simply eats into 'your economies'. And for you individuals, the most important thing is for you voters to ensure that 'your governments' do what YOU need - in all ways. So all of you make sure that this is authenticated and implemented - I suggest you do that now.

P.S. - Oh, by the way, we forgot to mention: the disgusting grabbers can never be trusted, so yes, sorry chaps, of course patents are already in progress - to exclude it from those of you who, simply for cash, would exclude it from the rest of us - Have the rest of you read that 'Strong Meat' book yet? - What a damned scandal it all is.


Well, that was how the position stood, but the patent was allowed to lapse after publication, so that now anyone can do it without fear of 'legal' repercussions.

Do it how? - Like this -

A few pseudo semi-technical twiddly-bits

It is said - by doctors - that p53 is not involved in all cancers.

Well, doctors generally say what they are told or have heard or read. Those of my experience haven't much head for things beyond departmental budgets and careers anyway. Perhaps they could not imagine that a p53 molecule with just a single electron at a different energy level - still 'demonstrably normal' p53, but now in reality an isotope - could code for 'abnormal' proteins that would result in cancer and death before any p53 variation were detectable. But that is just how subtly p53 mutation usually occurs. It generally does not change radically and immediately.

So let us humour those doctors and assume for a moment p53 involvement in only some cases. How to produce the vaccine to stimulate others' immune systems to act against cancers and potential cancers in the cases in which they do admit p53 implication - and in reality in most if not all of the rest?

Specify your target DNA, and isolate its p53. Multiply the p53 by PCR until you have enough of it to divide into eight or ten. Then treat each portion of p53 individually by the appropriate measure: beta and slow alpha particle damage, gamma-ray, x-ray and u.v. irradiation, exposure to mould, virus and heat etc. Then either multiply each treated portion by PCR and mix the portions, or mix all the treated portions first and then multiply the total by PCR, whichever proves the more practical. Result? - Vaccine of alien p53 to promote in the vaccinated subjects the production of antibodies against all forms of damaged p53 and therefore protection against most if not all forms of cancer in the future.

Very general? Of course it is. It is for the molecular biologists and computer technicians to be particular, and practically, not for you and me endlessly and theoretically. In this way we might be getting somewhere, quite soon.

Any questions?

Right. Then get on with it.

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